Медицинская библиотека · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2000

Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology?

Yamani M H, van de Poll S W, Ratliff N B, Kuban B E, Starling R C, McCarthy P M, Young J B

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate.

METHODS

We obtained fluorescence and reflectance spectra on 37 human endomyocardial biopsy specimens and correlated the spectra with International Society Heart and Lung Transplantation grade for histologic rejection.

RESULTS

Using different excitation wavelengths (ultraviolet, lambda = 337 nm; blue, lambda = 440 nm, and green, lambda = 486 nm), we found no significant difference in the fluorescence spectra among the different grades of rejection.

CONCLUSIONS

Fluorescence spectroscopy is not a sensitive method for detecting rejection in human heart transplant recipients.

Для цитирования: Yamani M H, van de Poll S W, Ratliff N B, Kuban B E, Starling R C, McCarthy P M, Young J B. Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology?. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2000. DOI: 10.1016/s1053-2498(00)00161-3.

Предметные рубрики MeSH

Adult Aged Animals Biopsy Endocardium Female Graft Rejection Heart Transplantation Humans Male Middle Aged Myocardium Predictive Value of Tests Rats Signal Processing, Computer-Assisted Spectrometry, Fluorescence

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