[Expression and significance of serum E-cadherin in patients with papillary thyroid carcinoma].

Objective:Experiments testing the concentration of serum E-cadherin were conducted through the patients with papillary thyroid carcinoma (PTC), nodular goiter and normal people. Combining the detection of E-cadherin protein in the tissues including papillary thyroid carcinoma,nodular goiter and normal thyroid tissues around adenoma,we analyze the effect and siginificance of E-cadherin in the papillary thyroid carcinoma.Method:The concentrations of E-cadherin in the serum of 86 cases of PTC patients, 16 cases of NG patients and 10 normal adults were detected by enzyme linked immunosorbent assay (ELISA) method, and the relationships between the serum level and clinical pathology characteristics of thyroid papillary carcinoma were explored. Western blot were used to detect the content of E-cadherin protein in tissues including PTC, nodular goiter tissues and normal thyroid tissues around adenoma.Result:The results showed that content of serum E-cadherin in PTC were significantly higher than those in nodular goiter tissues and normal thyroid issues (P< 0.05). There were no obviously differences between nodular goiter tissues and normal thyroid issues in the content of E-cadherin (P> 0.05). The content of E-cadherin protein in the tissues of PTC was evidently lower than those in nodular goiter tissues and normal thyroid tissues around adenoma (P< 0.05). There were no obviously differences between nodular goiter tissues and normal thyroid tissues around adenoma in the content of E-cadherin (P> 0.05). The abnormal expression of serum E-cadherin was correlated with the lymph node metastasis and pathological stage of PTC (P< 0.05). On the other hand,it is irrelevant to the gender､age and the tumor size of the patients (P> 0.05).Conclusion:The up-regulation of serum E-cadherin is correlated with the lymph node metastasis and pathological stage of PTC. The detection of the serum E-cadherin content plays a vital role in the aspects of early diagnosis and prognosis evaluation.