A Pilot Study Evaluating Associations between Continuous Glucose Monitoring Metrics in Pregnancy and Postpartum A1c and Blood Pressure.

OBJECTIVE

This study aimed to examine the relationship between continuous glucose monitoring (CGM) metrics during gestational diabetes mellitus (GDM)-affected pregnancy and postpartum cardiometabolic measures in a pilot study.

STUDY

DESIGN

We enrolled participants >6 months postpartum from a previous GDM trial where they wore a CGM during the third trimester. At the postpartum visit, we assessed hemoglobin A1c (HbA1c) and blood pressure (BP). We used linear regression models adjusted for age and body mass index (BMI) at the time of CGM wear to test for a relationship between pregnancy CGM metrics (mean glucose, coefficient of variation, time in pregnancy range 63-140 mg/dL [pTIR], time >120 and >140 mg/dL) and postpartum outcomes (HbA1c and BP).

RESULTS

Of 14 eligible participants with pregnancy CGM data, 11 (79%) returned at a mean of 20.3 months postpartum (range 11-33). Age and BMI during pregnancy CGM wear were 36.0 (2.7) years and 28.7 (5.5) kg/m 2 ; gestational age was 32.0 (2.0) weeks. Higher pTIR was associated with lower postpartum HbA1c ( n  = 8, β = -0.06, p  = 0.007). Other CGM metrics were not associated with HbA1c. There were no associations between CGM metrics and BP.

CONCLUSION

Third-trimester CGM pTIR should be tested as a predictor of postpartum glycemia in a larger study.