Total Synthesis, Determination of Absolute Configuration, Antibacterial Efficacy of Colletotrichumolide, and Its 3R-Diastereomer.

Total synthesis and determination of absolute configuration of colletotrichumolide 2 and its 3R-diastereomer 3 have been achieved by Julia-Kociennski olefination, Shiina lactonization, chemo- and regioselective epoxide opening, and Mitsunobu reaction as key steps. Synthesized compounds (2-3) were tested for their antibacterial activity against two of the most resilient bacterial strains, Enterococcus faecalis and Staphylococcus aureus, and they were found to show significant antibacterial activity against S. aureus and E. faecalis cell lines.