Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
Evaluation of N-Butyl Cyanoacrylate Tissue Adhesive for Second Intention Healing Following Dermatologic Surgery: A Randomized Controlled Trial.
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Nusrat Faria, Scherz Luke A, Walkosak Carissa, Jennings Tara, Lawrence Naomi
Аннотация
BACKGROUND: Second intention healing is a frequent choice after dermatologic surgery, but prolonged wound care and daily dressings can pose practical challenges for patients. Tissue adhesives offer a low-maintenance alternative; however, their role in second intention healing remains underexplored.
OBJECTIVE: To evaluate the efficacy of n-butyl cyanoacrylate tissue adhesive on second intention healing compared with the standard of care using petroleum-based dressings.
METHODS: In this randomized controlled trial, 47 patients with postoperative wounds of the hands, feet, or genital region after Mohs micrographic surgery or excision received standard of care (n = 22) or tissue adhesive (n = 25). At 2 weeks postoperation, the tissue adhesive group was rerandomized to receive standard of care (n = 13) or tissue adhesive (n = 12). All patients received standard of care for the remainder of the study. Re-epithelialization, postoperative complications, and patient satisfaction were recorded at the 2-, 4-, and 12-week postoperative follow-up visits.
RESULTS: Re-epithelialization, postoperative complication rates, and patient satisfaction scores were comparable among groups (p > .05).
CONCLUSION: Tissue adhesive is a viable alternative to the standard of care for second intention healing, simplifying postoperative management without compromising healing outcomes or patient satisfaction.
OBJECTIVE: To evaluate the efficacy of n-butyl cyanoacrylate tissue adhesive on second intention healing compared with the standard of care using petroleum-based dressings.
METHODS: In this randomized controlled trial, 47 patients with postoperative wounds of the hands, feet, or genital region after Mohs micrographic surgery or excision received standard of care (n = 22) or tissue adhesive (n = 25). At 2 weeks postoperation, the tissue adhesive group was rerandomized to receive standard of care (n = 13) or tissue adhesive (n = 12). All patients received standard of care for the remainder of the study. Re-epithelialization, postoperative complications, and patient satisfaction were recorded at the 2-, 4-, and 12-week postoperative follow-up visits.
RESULTS: Re-epithelialization, postoperative complication rates, and patient satisfaction scores were comparable among groups (p > .05).
CONCLUSION: Tissue adhesive is a viable alternative to the standard of care for second intention healing, simplifying postoperative management without compromising healing outcomes or patient satisfaction.