Science (New York, N.Y.) · 2019
Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Lovett Brian, Bilgo Etienne, Millogo Souro Abel, Ouattarra Abel Kader, Sare Issiaka, Gnambani Edounou Jacques, Dabire Roch K, Diabate Abdoulaye, St Leger Raymond J
Аннотация
Malaria control efforts require implementation of new technologies that manage insecticide resistance. Metarhizium pingshaense provides an effective, mosquito-specific delivery system for potent insect-selective toxins. A semifield trial in a MosquitoSphere (a contained, near-natural environment) in Soumousso, a region of Burkina Faso where malaria is endemic, confirmed that the expression of an insect-specific toxin (Hybrid) increased fungal lethality and the likelihood that insecticide-resistant mosquitoes would be eliminated from a site. Also, as Hybrid-expressing M. pingshaense is effective at very low spore doses, its efficacy lasted longer than that of the unmodified Metarhizium Deployment of transgenic Metarhizium against mosquitoes could (subject to appropriate registration) be rapid, with products that could synergistically integrate with existing chemical control strategies to avert insecticide resistance.