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DOI 10.1007/s00277-026-06737-3

Медицинская библиотека · Annals of hematology · 2026

Hypomethylating agents alone or in combination with venetoclax in very elderly acute myeloid leukemia patients: less treatment, better care?

Tarantini Francesco, Contento Corinne, Vigna Ernesto, Carluccio Vera, Greco Giuseppina, Pasciolla Crescenza, Ciuffreda Lucia, Rossi Giovanni, Urbano Marina Aurora, D'Ambrosio Alessandro, Aprile Lara, Gagliardi Vito Pier, Delia Mario, Attolico Immacolata, Carluccio Paola, Federico Vincenzo, Bruzzese Antonella, Di Renzo Nicola, Gentile Massimo, Tarantini Giuseppe, Mele Anna, Guarini Attilio, Melillo Lorella Maria Antonia, Carella Angelo Michele, Pastore Domenico, Frigeri Ferdinando, Maggi Alessandro, Cumbo Cosimo, Specchia Giorgina, Musto Pellegrino, Albano Francesco

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Аннотация

Hypomethylating agents (HMA) alone or in combination with venetoclax (VEN) are a mainstay for disease control in elderly acute myeloid leukemia (AML). We evaluated the non-inferiority of HMA monotherapy compared to HMA/VEN combination in 227 AML patients aged ≥ 75 years receiving HMA or HMA/VEN combination. No difference in overall survival (OS) was observed between the two groups, with HMA monotherapy demonstrating statistical non-inferiority. HMA-treated patients with favorable performance status had longer OS. The HMA/VEN group experienced higher mortality and worse QoL. HMA monotherapy offers comparable survival outcomes to HMA/VEN with reduced toxicity in elderly AML patients.

Для цитирования: Tarantini Francesco, Contento Corinne, Vigna Ernesto, Carluccio Vera, Greco Giuseppina, Pasciolla Crescenza, Ciuffreda Lucia, Rossi Giovanni, Urbano Marina Aurora, D'Ambrosio Alessandro, Aprile Lara, Gagliardi Vito Pier, Delia Mario, Attolico Immacolata, Carluccio Paola, Federico Vincenzo, Bruzzese Antonella, Di Renzo Nicola, Gentile Massimo, Tarantini Giuseppe, Mele Anna, Guarini Attilio, Melillo Lorella Maria Antonia, Carella Angelo Michele, Pastore Domenico, Frigeri Ferdinando, Maggi Alessandro, Cumbo Cosimo, Specchia Giorgina, Musto Pellegrino, Albano Francesco. Hypomethylating agents alone or in combination with venetoclax in very elderly acute myeloid leukemia patients: less treatment, better care?. Annals of hematology. 2026. DOI: 10.1007/s00277-026-06737-3.

Предметные рубрики MeSH

HumansBridged Bicyclo Compounds, HeterocyclicSulfonamidesLeukemia, Myeloid, AcuteAntineoplastic Combined Chemotherapy ProtocolsAgedAged, 80 and overFemaleMaleDecitabineDNA Methylation
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