Clostridium perfringens endophthalmitis.

Our report describes a 35 year-old male who sustained a penetrating injury with an intraocular foreign body and developed endophthalmitis. Gram stain showed Gram positive bacilli and culture grew Clostridium perfringens. The patient was managed successfully by therapeutic vitrectomy and intravitreal and systemic antibiotic therapy. Early vitrectomy and intravitreal antibiotics should be considered in patients who develop severe endophthalmitis following penetrating injury.