Korean journal of radiology · 2026
Prognostic Implications of CT- and MRI-Based LI-RADS Category M Features in Intrahepatic Cholangiocarcinoma: An Intraindividual Comparison.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jung Yong Jun, Choi Eun Sun, Kim Dong Hwan, Choi Sang Hyun, Lee Seung Soo, Byun Jae Ho, Won Hyung Jin, Shin Yong Moon
Аннотация
OBJECTIVE: Liver Imaging Reporting and Data System category M (LR-M) is associated with a poor prognosis in intrahepatic cholangiocarcinoma (iCCA). However, the prognostic value of individual LR-M features across imaging modalities remains unclear. We aimed to determine, through intraindividual comparisons, whether the prognostic value of individual LR-M features differs between CT and MRI in patients with iCCA at risk for hepatocellular carcinoma.
MATERIALS AND METHODS: This retrospective study included consecutive patients with cirrhosis or chronic hepatitis B who underwent curative-intent resection for iCCA and preoperative multiphasic CT and MRI between 2010 and 2019. CT and MRI images were reviewed in separate sessions ≥4 weeks apart. Cox proportional hazards regression analyses with and without adjustment for LI-RADS categorization (non-LR-M vs. single-modality LR-M or dual-modality LR-M) were performed to evaluate the associations of CT- and MRI-based targetoid and non-targetoid LR-M features and other variables with recurrence-free survival (RFS) and overall survival (OS).
RESULTS: A cohort of 122 patients (mean age, 57.9 ± 10.4 years) was included. MRI demonstrated significantly higher frequencies than CT for targetoid (84.4% vs. 73.8%, P = 0.007) and non-targetoid features (43.4% vs. 20.5%, P < 0.001), resulting in a higher rate of LR-M categorization (90.2% vs. 81.1%, P = 0.003). In the multivariable analysis, CT-based targetoid features (hazard ratio [HR] = 2.31 for RFS, P = 0.010; HR = 1.85 for OS, P = 0.043) and MRI-based non-targetoid features (HR = 2.15 for RFS, P = 0.005; HR = 2.09 for OS, P = 0.008) were independently associated with poorer survival. After adjustment for LI-RADS categorization, MRI-based non-targetoid features remained independently associated with poorer RFS (HR = 1.76, P = 0.041) and OS (HR = 1.79, P = 0.038). Dual-modality LR-M designation was independently associated with poorer RFS (HR = 8.02, P = 0.042).
CONCLUSION: The prognostic implications of LR-M features in iCCA vary by imaging modality and feature type. CT-based targetoid and MRI-based non-targetoid features were associated with poorer survival, and the associations between MRI-based non-targetoid features and survival remained significant after adjustment for LI-RADS categorization.
MATERIALS AND METHODS: This retrospective study included consecutive patients with cirrhosis or chronic hepatitis B who underwent curative-intent resection for iCCA and preoperative multiphasic CT and MRI between 2010 and 2019. CT and MRI images were reviewed in separate sessions ≥4 weeks apart. Cox proportional hazards regression analyses with and without adjustment for LI-RADS categorization (non-LR-M vs. single-modality LR-M or dual-modality LR-M) were performed to evaluate the associations of CT- and MRI-based targetoid and non-targetoid LR-M features and other variables with recurrence-free survival (RFS) and overall survival (OS).
RESULTS: A cohort of 122 patients (mean age, 57.9 ± 10.4 years) was included. MRI demonstrated significantly higher frequencies than CT for targetoid (84.4% vs. 73.8%, P = 0.007) and non-targetoid features (43.4% vs. 20.5%, P < 0.001), resulting in a higher rate of LR-M categorization (90.2% vs. 81.1%, P = 0.003). In the multivariable analysis, CT-based targetoid features (hazard ratio [HR] = 2.31 for RFS, P = 0.010; HR = 1.85 for OS, P = 0.043) and MRI-based non-targetoid features (HR = 2.15 for RFS, P = 0.005; HR = 2.09 for OS, P = 0.008) were independently associated with poorer survival. After adjustment for LI-RADS categorization, MRI-based non-targetoid features remained independently associated with poorer RFS (HR = 1.76, P = 0.041) and OS (HR = 1.79, P = 0.038). Dual-modality LR-M designation was independently associated with poorer RFS (HR = 8.02, P = 0.042).
CONCLUSION: The prognostic implications of LR-M features in iCCA vary by imaging modality and feature type. CT-based targetoid and MRI-based non-targetoid features were associated with poorer survival, and the associations between MRI-based non-targetoid features and survival remained significant after adjustment for LI-RADS categorization.