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Войти в исследования Cardiac resynchronisation therapy among adults with a systemic right ventricle: a multicentre experience.
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Fusco Flavia, Scognamiglio Giancarlo, Dellborg Mikael, Dehghani Payam, Jameson Susan M, Kay W Aaron, Cramer Jonathan W, Vonder Muhll Isabelle, Krieger Eric V, Rodriguez Fred H, Burchill Luke J, Nicolarsen Jeremy, Kay Joseph, Kauling Robert M, Shah Sangeeta, Magalski Anthony, Wong Joshua, Celermajer David S, Baker David William, Roos-Hesselink Jolien W, Ginde Salil, Aboulhosn Jamil, Kuo Marissa, DeZorzi Christopher, Khairy Paul, Rodriguez-Monserrate Carla P, Kutty Shelby, Wilson William, Lubert Adam M, Grewal Jasmine, Han Frank, Cotts Timothy, Pylypchuk Stephen, Gupta Tripti, Antonová Petra, O'Donnell Clare, John Anitha, Gallego Pastora, van Dissel Alexandra, Opotowsky Alexander R, Yeung Elizabeth, Broberg Craig S, Sarubbi Berardo
Аннотация
METHODS: This is an international, retrospective study including patients >18 years from 33 centres with transposition of the great arteries (TGA) following atrial switch operation and congenitally corrected TGA. The primary endpoint included overall survival and survival free from HF. The secondary endpoint was a composite of death, hospitalisation for HF, heart transplant, mechanical support and ventricular tachycardia/implantable cardioverter-defibrillator therapies.
RESULTS: We identified 105 out of 1721 patients (3.5%) who underwent CRT. Median follow-up after CRT implant was 4.6 (1.6-8) years. QRS improvement was limited to those with previous pacing (167±35 vs 154±28 ms; p=0.002). Following CRT, there was no significant change in B-type natriuretic peptide values, peak VO2 and tricuspid regurgitation severity by echocardiography. CRT complications occurred in 10 (9.5%), though they were usually minor. Patients with CRT were propensity-matched to controls according to age, sex, anatomy, presence of complex disease, previous HF and sRV dysfunction at baseline. At univariable analysis, CRT (HR 4.39-95%, CI 1.6 to 11.9; p=0.003), older age and moderate-to-severe sRV dysfunction at baseline were predictive of death, while CRT (HR 3-95%, CI 1.3 to 7; p=0.01) and sRV dysfunction were associated with HF admission. By multivariable analysis, CRT (HR 8.8-95%, CI 2.9 to 26.6; p=0.0001) and age (HR 1.1%-95%, CI 1.01 to 1.15; p<0.0001) were independently associated with poorer outcome.
CONCLUSION: In this retrospective study in the largest population thus far described with an sRV, CRT implant was not associated with improved survival, even after controlling for key confounders.