Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2003
Transfusion-related problems following major ABO-incompatible bone marrow transplantation.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tasaki Tetsunori, Satoh Shyukuko, Gotoh Kenji, Fujii Kieko, Sasaki Sakiko, Takadate Junko, Tachibana Mihoko, Ono Yoko, Ishida Yoji
Аннотация
A case of acute myelocytic leukemia has been reported in which the patient's surviving original B lymphocytes after pretransplant-conditioning chemotherapy probably reproduced hemagglutinins that reacted with red blood cells (RBCs) derived from engrafted donor marrow for a prolonged period of time. Although the direct antiglobulin test was negative and hemagglutinins were not detectable in the patient's sera but only in the eluate, the antibodies reappeared in the sera. Therefore, it is important to confirm that the eluate does not contain antibodies that would react with donor-derived RBCs when the type of red cell used for transfusion is switched from the patient's type to the donor's type in a major ABO-mismatched bone marrow transplantation (BMT). Testing of ABO subgroups using lectins is also recommended to avoid a delayed hemolytic transfusion reaction following BMT.