British journal of haematology · 2001
Biological and molecular characterization of PNH-like lymphocytes emerging after Campath-1H therapy.
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Fracchiolla N S, Barcellini W, Bianchi P, Motta M, Fermo E, Cortelezzi A
Аннотация
Campath-1H, an anti-CD52 monoclonal antibody, is therapeutically active in lymphoproliferative and autoimmune diseases. After Campath-1H therapy, lymphocytes with a paroxysmal nocturnal haemoglobinuria (PNH) phenotype have been reported to emerge. We characterized a PNH-like lymphocyte population emerging after Campath-1H therapy, in a patient with fludarabine refractory B-cell chronic lymphocytic leukaemia (B-CLL). We demonstrated a reduction in PIG-A mRNA levels compared with controls, and of all cytokines tested [interleukin (IL)-4, IL-13, IL-2, interferon(IFN)-gamma, IL-6, IL-10, and tumour necrosis factor (TNF)-alpha], except transforming growth factor (TGF)-beta. Given the inhibitory activity of TGF-beta, its elevated levels may contribute to the selective pressure of Campath-1H, leading to the emergence of PNH-like lymphocytes.
Предметные рубрики MeSH
AlemtuzumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntibodies, NeoplasmCase-Control StudiesFlow CytometryHemoglobinuria, ParoxysmalHumansInterferon-gammaInterleukin-10Interleukin-13Interleukin-2Interleukin-4Interleukin-6Leukemia, Lymphocytic, Chronic, B-CellLymphocytesMaleMembrane ProteinsMiddle AgedPhytohemagglutininsPolymorphism, Single-Stranded ConformationalRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alpha