Photocatalytic In Situ Media-Promoted Cascade for Direct Synthesis of Long-Chain Aryl Ketones via γ-C(sp3)-H Activation.

A novel photocatalytic strategy is described for carbonylative difunctionalization of unactivated γ-C(sp3)-H bonds with alkenes. Building on a reductively initiated radical pathway from N-O reagents in combination with a 1,5-hydrogen atom transfer (HAT) process, this approach enables the synthesis of aryl ketones under metal-free conditions, mitigating competitive β-hydride elimination pathways.