Association between hemoglobin level and clinical outcomes in ischemic stroke patients with high-grade carotid artery stenosis.

OBJECTIVE

Abnormal hemoglobin levels may influence stroke outcome, while high-grade carotid artery stenosis (CAS) is linked to distal hemodynamic compromise. The relationship between hemoglobin and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate this association in acute IS patients with high-grade CAS.

METHODS

To compare the characteristics and outcome in acute IS patients with high-grade CAS across different hemoglobin levels, we conducted an observational cohort study from January 2007 to April 2012 and followed for 5 years.

RESULTS

Among 372 enrolled patients, 75 had hemoglobin < 12 g/dL, 153 had 12-14 g/dL, and 144 had > 14 g/dL. Hemoglobin < 12 g/dL was associated with higher rates of congestive heart failure, gout, and chronic kidney disease, but lower rate of hyperlipidemia. Hemoglobin< 12 g/dL had lower levels of white blood cells, total cholesterol, and estimated glomerular filtration rate, but higher levels of high-sensitivity C-reactive protein and potassium. The Cox proportional hazards model revealed that hemoglobin< 12 g/dL was associated with higher risk of all-cause mortality (hazard ratio (HR) 1.99, 95 % confidence interval (CI) 1.20-3.32, P = 0.008) and lower risk of stroke recurrence over 5 years in IS patients with high-grade CAS (HR 0.50, 95 % CI 0.26-0.95; P = 0.033).

CONCLUSIONS

Hemoglobin< 12 g/dL was associated with higher mortality and lower stroke recurrence risk over 5 years in IS patients with high-grade CAS. Further studies are warranted to determine the optimal hemoglobin level for improving outcomes in these patients.