Decoding Cell-Cell Communications in Alveolar during Infection: Metabolic Control.

In this issue of Cell Host & Microbe, Liu et al. elucidates how Legionella-infected macrophages use the alveolar epithelium to metabolically process myeloid cells and advance antibacterial inflammation. This highlights the alveolar epithelium's importance as a key signaling bridge and could yield a metabolism-based blueprint for hampering Legionnaires' disease.