Copper-Mediated Dehydroamination of Primary Amines for Olefination.

Herein, we introduce a versatile and effective copper-mediated approach for the dehydroamination of a wide range of primary amines encompassing complex bioactive compounds. This method facilitates the transformation of primary amines into olefins under mild conditions, proceeding through a distinctive reaction mechanism. The process involves the formation of the monosubstituted isodiazene intermediate, which undergoes copper-mediated oxidative elimination to yield the corresponding alkene.