Tc-99m DTPA renography in patients with collagen disease.

PURPOSE: This study evaluated the use of Tc-99m DTPA renography in patients with collagen disease.

MATERIALS AND

METHODS

Tc-99m DTPA renal scintigraphy was performed in 28 patients with clinically diagnosed collagen disease. Twenty-two other patients who underwent renal scintigraphy and were subsequently shown to have no kidney abnormalities served as the control group.

RESULTS

One quarter of the patients with collagen disease had abnormal findings of renography, despite the absence of abnormal laboratory data. Renograms were 100% sensitive for the detection of renal disease in patients with collagen disease, and their specificity was 53% when serum blood urea nitrogen, serum creatinine concentration, and proteinuria were the only measures of renal impairment considered. The glomerular filtration rate was not significantly different between the groups, but the bilateral time to peak was significantly greater in the patients with collagen disease. Hydronephrosis was present in 7% of patients with collagen disease.

CONCLUSION

Renography is useful for detecting early changes of renal involvement when the clinical state of collagen disease is evaluated.