Archives of oral biology · 2023
Effect of an experimental TiF4/NaF solution in preventing tooth erosion.
Рандомизированное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Vertuan Mariele, da Silva Júlia França, de Souza Beatriz Martines, Braga Aline Silva, Magalhães Ana Carolina
Аннотация
OBJECTIVE: This was a randomized, double-blind, parallel, placebo-controlled in vivo study investigating the protective potential of a titanium tetrafluoride/ sodium fluoride (TiF4/NaF) solution compared to its respective positive and negative controls under an in vivo model, as well as the perception of participants regarding the use of this experimental solution.
METHODS: After the ethics approval and the selection procedures, 33 participants were divided into three treatments: TiF4/NaF solution (500 ppm F, pH 4.4); AmF/NaF/SnCl2-mouthwash (500 ppm F, pH 4.5) and water (pH 7.0) (n = 11). After professional cleaning, the participants rinsed with one of the solutions for one minute and waited two hours for the erosive challenge. The erosive solution (1 % citric acid, pH 2.5) was applied for 10 s on each central incisor (enamel area: 4 mm2) and collected for calcium analysis using III Arsenazo colorimetric method. The Ca2+ release data were compared using Kruskal-Wallis/ Dunn tests (p < 0.05).
RESULTS: Teeth treated with both fluoride solutions released less calcium into the acid (median and interquartile interval: TiF4/NaF - 0.45/0.19 mM and AmF/NaF/SnCl2 - 0.46/0.15 mM Ca2+, p = 0.99) compared to the negative control (1.12/0.42 mM Ca2+, 60 % reduction, p < 0.0006). For both F solutions, only one participant per group reported unpleasant taste. Four participants belonging to AmF/NaF/SnCl2-mouthwash reported burning sensation post-rinse, while only one participant described such feeling after TiF4/NaF rinsing.
CONCLUSION: The experimental TiF4/NaF solution was as effective as the commercial AmF/NaF/SnCl2-mouthwash in protecting enamel against erosive demineralization with a good acceptability by the participants.
METHODS: After the ethics approval and the selection procedures, 33 participants were divided into three treatments: TiF4/NaF solution (500 ppm F, pH 4.4); AmF/NaF/SnCl2-mouthwash (500 ppm F, pH 4.5) and water (pH 7.0) (n = 11). After professional cleaning, the participants rinsed with one of the solutions for one minute and waited two hours for the erosive challenge. The erosive solution (1 % citric acid, pH 2.5) was applied for 10 s on each central incisor (enamel area: 4 mm2) and collected for calcium analysis using III Arsenazo colorimetric method. The Ca2+ release data were compared using Kruskal-Wallis/ Dunn tests (p < 0.05).
RESULTS: Teeth treated with both fluoride solutions released less calcium into the acid (median and interquartile interval: TiF4/NaF - 0.45/0.19 mM and AmF/NaF/SnCl2 - 0.46/0.15 mM Ca2+, p = 0.99) compared to the negative control (1.12/0.42 mM Ca2+, 60 % reduction, p < 0.0006). For both F solutions, only one participant per group reported unpleasant taste. Four participants belonging to AmF/NaF/SnCl2-mouthwash reported burning sensation post-rinse, while only one participant described such feeling after TiF4/NaF rinsing.
CONCLUSION: The experimental TiF4/NaF solution was as effective as the commercial AmF/NaF/SnCl2-mouthwash in protecting enamel against erosive demineralization with a good acceptability by the participants.