[Network Meta-analysis of TCM injections combined with conventional western medicine in treatment of viral pneumonia].

Network Meta-analysis was conducted to evaluate the efficacy and safety of different TCM injections combined with conventional western medicine in the treatment of viral pneumonia. A comprehensive computerized search was performed in CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, EMbase, and Cochrane Library. The search period was from 1 January 2015 to 1 July 2025. EndNote, RevMan 5.3, and Stata 17 software were used for literature screening and statistical analysis. A total of 1 605 relevant publications were identified, and 74 randomized controlled trials(RCTs) involving 8 types of TCM injections were ultimately included. Network Meta-analysis revealed that:(1) for improving the clinical total effective rate, the intervention with the highest SUCRA ranking was Qingkailing Injection + conventional western medicine;(2) for reducing cough resolution time, the intervention with the highest SUCRA ranking was Yanhuning Injection + conventional western medicine;(3) for reducing the time to resolution of pulmonary rales, the intervention with the highest SUCRA ranking was Yanhuning Injection + conventional western medicine;(4) for reducing fever duration, the intervention with the highest SUCRA ranking was Shenqi Fuzheng Injection + conventional western medicine;(5) for reducing the hospitalization duration, the intervention with the highest SUCRA ranking was Yanhuning Injection + conventional western medicine;(6) for improving CRP, the intervention with the highest SUCRA ranking was Yanhuning Injection + conventional western medicine;(7) for improving IL-6, the intervention with the highest SUCRA ranking was Tanreqing Injection + conventional western medicine;(8) for improving TNF-α, the intervention with the highest SUCRA ranking was Yanhuning Injection + conventional western medicine;(9) regarding safety, compared with conventional western medicine alone, combining TCM injections with conventional western medicine did not show an obvious increase in adverse reactions, and no serious adverse reactions occurred. The results indicate that TCM injections combined with conventional western medicine can effectively improve the overall clinical response rate in patients with viral pneumonia, reduce the time to clinical symptom resolution, and improve CRP, IL-6, and TNF-α. Due to limitations in the included studies, more large-sample, multicenter, randomized double-blind trials are required to provide higher-quality evidence for the use of TCM injections in the treatment of viral pneumonia.