Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2008
[The significance and characteristics of distribution of beta-endorphin and mu-opioid receptors in normal skin and hyperplastic scar].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Cheng Biao, Liu Hong-Wei, Li Qin, Fu Xiao-Bing, Sheng Zhi-Yong, Cao Rong
Аннотация
OBJECTIVE: To detect the distribution of beta-endorphin and mu-opioid receptors (MOR) in normal skin tissue and scar tissue from healthy volunteers and patients with hypertrophic scar.
METHODS: Normal skin samples from 10 healthy individuals and 10 patients with hypertrophic scar, and scar samples from the same 10 patients were investigated. The beta-endorphin and MOR protein in the samples were detected by immunofluorescence (IF). The reverse transcription polymerase chain reaction (RT-PCR) was used to detect MOR mRNA.
RESULTS: Beta-endorphin and MOR protein were expressed in all samples. There were no significant differences in the expression of beta-endorphin and MOR protein between normal skin from healthy volunteers and patients with hypertrophic scar (P > 0.05). The expression of beta-endorphin, MOR protein and mRNA in hyperplastic scar was significantly stronger than that in normal skin (P < 0.01).
CONCLUSIONS: The expression of beta-endorphin and MOR is different in normal skin and hypertrophic scar. This maybe the possible reason of scar paresthesia.
METHODS: Normal skin samples from 10 healthy individuals and 10 patients with hypertrophic scar, and scar samples from the same 10 patients were investigated. The beta-endorphin and MOR protein in the samples were detected by immunofluorescence (IF). The reverse transcription polymerase chain reaction (RT-PCR) was used to detect MOR mRNA.
RESULTS: Beta-endorphin and MOR protein were expressed in all samples. There were no significant differences in the expression of beta-endorphin and MOR protein between normal skin from healthy volunteers and patients with hypertrophic scar (P > 0.05). The expression of beta-endorphin, MOR protein and mRNA in hyperplastic scar was significantly stronger than that in normal skin (P < 0.01).
CONCLUSIONS: The expression of beta-endorphin and MOR is different in normal skin and hypertrophic scar. This maybe the possible reason of scar paresthesia.