Clinical neurology and neurosurgery · 2025
Clinical and etiological characteristics of catatonic disorder due to another medical condition: A retrospective study from a tertiary care center.
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Altunç Ali Tarık, Emre Doğukan Hazar, Gündüz Ayşegül, Poyraz Burç Çağrı
Аннотация
OBJECTIVES: The aim of this study was to investigate the demographic, clinical, and etiological characteristics of patients diagnosed with catatonic disorder due to another medical condition.
METHODS: A retrospective analysis was conducted on 18 patients diagnosed with catatonic disorder due to another medical condition in a tertiary care center between 2017 and 2024. Patient demographics, underlying medical conditions, clinical features, and treatment methods were documented.
RESULTS: Eighteen patients met the inclusion criteria. The most frequent underlying conditions were neurodegenerative diseases (6/18), autoimmune encephalitis (4/18), and the use of antipsychotic medications (5/18), often in the presence of comorbid neurological disorders. Commonly observed symptoms included mutism, negativism, and rigidity. Benzodiazepines were the initial treatment in most cases (11/18). Among these 9/18 received lorazepam, 4/18 received alprazolam and 1/18 received clonazepam. Following benzodiazepine treatment, many patients required additional interventions such as electroconvulsive therapy (6/18), memantine (4/18), or amantadine (3/18). Overall, approximately 60 % of patients achieved full remission, whereas others showed only partial improvement.
CONCLUSIONS: Catatonic disorder due to another medical condition appears to present with diverse underlying causes and clinical manifestations. Although benzodiazepines are generally considered the first-line treatment, additional interventions were often needed. These findings underline the importance of clinical awareness and timely management, while further research is required to better understand prognostic factors and to guide treatment strategies.
METHODS: A retrospective analysis was conducted on 18 patients diagnosed with catatonic disorder due to another medical condition in a tertiary care center between 2017 and 2024. Patient demographics, underlying medical conditions, clinical features, and treatment methods were documented.
RESULTS: Eighteen patients met the inclusion criteria. The most frequent underlying conditions were neurodegenerative diseases (6/18), autoimmune encephalitis (4/18), and the use of antipsychotic medications (5/18), often in the presence of comorbid neurological disorders. Commonly observed symptoms included mutism, negativism, and rigidity. Benzodiazepines were the initial treatment in most cases (11/18). Among these 9/18 received lorazepam, 4/18 received alprazolam and 1/18 received clonazepam. Following benzodiazepine treatment, many patients required additional interventions such as electroconvulsive therapy (6/18), memantine (4/18), or amantadine (3/18). Overall, approximately 60 % of patients achieved full remission, whereas others showed only partial improvement.
CONCLUSIONS: Catatonic disorder due to another medical condition appears to present with diverse underlying causes and clinical manifestations. Although benzodiazepines are generally considered the first-line treatment, additional interventions were often needed. These findings underline the importance of clinical awareness and timely management, while further research is required to better understand prognostic factors and to guide treatment strategies.