Maffucci's syndrome complicated by carcinoma of the breast, pituitary adenoma, and mediastinal hemangioma.

We have described a 39-year-old woman with Maffucci's syndrome, large mediastinal hemangiomas, infiltrating adenocarcinoma of the breast, and pituitary adenoma. This is the fifth reported case of Maffucci's syndrome with a coexistent pituitary adenoma, a frequency that cannot be explained by chance alone. There has been only one previously reported case in which the patient had a widened mediastinum, but the etiology was not discussed. Three of the four previously described patients with Maffucci's syndrome and a pituitary adenoma also had a proven or possible associated epithelial neoplasm. While this association is tenuous, it is considered worthy of comment.