TBX22 and tongue-tie.

OBJECTIVE

To resolve if TBX22 mutations cause isolated tongue-tie in the Finnish population.

DESIGN

Mutation analysis of the coding region of the TBX22 gene in 50 Finnish isolated tongue-tie patients and 61 control samples.

RESULTS

One putative sequence variation was identified from two male patients, but whether this represents a polymorphism or causative mutation remains unknown.

CONCLUSIONS

Mutations in the coding region of the TBX22 gene are not a major cause of ankyloglossia in the Finnish population and do not explain the sex difference or inheritance of tongue-tie.