[Rinsho ketsueki] The Japanese journal of clinical hematology · 2026
[Thiotepa-busulfan-fludarabine conditioning in allogeneic hematopoietic stem cell transplantation for blast-phase myeloproliferative neoplasm].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Abe Shintaro, Izumi Shintaro, Tsukamoto Shokichi, Miyamoto Izumi, Yoda Natsumi, Tanaka Kazusuke, Matsumura Gai, Koyama Gentaro, Konno Shiho, Hamada Chihiro, Otani Ko, Kirito Keisuke, Shioiri Yuto, Isogai Shuntaro, Kubodera Ai, Nakajima Akihiro, Kato Rei, Tanami Takaaki, Nishihara Ayaka, Ri Chihiro, Matsui Shinichiro, Ishii Arata, Oshima-Hasegawa Nagisa, Takeda Yusuke, Mimura Naoya, Sakaida Emiko
Аннотация
INTRODUCTION: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative option for blast-phase myeloproliferative neoplasms (BP-MPN), although relapse rates remain high. Recently, conditioning with thiotepa, busulfan, and fludarabine (TBF) has shown promising anti-leukemic activity in acute myeloid leukemia.
CASE REPORT: A 64-year-old man with essential thrombocythemia that progressed to secondary myelofibrosis and subsequently BP-MPN underwent allo-HSCT after cytoreduction with azacitidine plus venetoclax. Peripheral blood stem cells were obtained from an HLA allele-matched unrelated donor, and TBF was used as the conditioning regimen. Low-dose anti-thymocyte globulin was administered for graft-versus-host disease (GVHD) prophylaxis. Full donor chimerism was achieved on day 28 after transplantation. Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) improved with defibrotide, and acute GVHD was manageable.
CONCLUSION: This case suggests that a multidisciplinary treatment strategy incorporating TBF conditioning may improve relapse-free survival in patients with BP-MPN.
CASE REPORT: A 64-year-old man with essential thrombocythemia that progressed to secondary myelofibrosis and subsequently BP-MPN underwent allo-HSCT after cytoreduction with azacitidine plus venetoclax. Peripheral blood stem cells were obtained from an HLA allele-matched unrelated donor, and TBF was used as the conditioning regimen. Low-dose anti-thymocyte globulin was administered for graft-versus-host disease (GVHD) prophylaxis. Full donor chimerism was achieved on day 28 after transplantation. Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) improved with defibrotide, and acute GVHD was manageable.
CONCLUSION: This case suggests that a multidisciplinary treatment strategy incorporating TBF conditioning may improve relapse-free survival in patients with BP-MPN.