Internal medicine (Tokyo, Japan) · 2016
Hematopoietic Stem Cell Transplantation Nephropathy Associated with Chronic Graft-versus-Host Disease without Extrarenal Involvement.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Ishida Ryo, Shimizu Akira, Kitani Takashi, Nakata Mayumi, Ota Noriyoshi, Kado Hiroshi, Shiotsu Yayoi, Ishida Mami, Tamagaki Keiichi
Аннотация
A 30-year-old woman with myelodysplastic syndrome underwent allogeneic hematopoietic stem cell transplantation (HSCT) derived from her HLA-matched sister six years previously. She received preconditioning total body irradiation with renal shielding and was subsequently administered cyclosporin A (CyA) as prophylaxis against graft-versus-host disease (GVHD). Four months after HSCT, asymptomatic proteinuria and glomerular hematuria developed during CyA tapering without obvious extrarenal involvements of GVHD, and persisted for six years. A renal biopsy revealed endothelial injury in the glomeruli, and the deposition of C4d was detected diffusely on glomerular capillaries and focally on peritubular capillaries, suggesting that nephropathy involved antibody- or complement-associated immune reactions.