Nickel-Catalyzed Direct Enantioselective Alkynylation of Alkynyl Bromide with Secondary Phosphine Oxides.

Developing a transition-metal-catalyzed method for the synthesis of chiral phosphorus-centered alkynyl compounds remains a considerable challenge. Herein, we report an asymmetric coupling reaction involving nickel-catalyzed alkynyl bromides and secondary phosphine oxides, obtaining a series of chiral alkynyl phosphorus compounds with high yields (up to 74%) and excellent stereoselectivity (up to 97% ee). This method features a broad substrate scope and mild reaction conditions.