Scleroderma of the breast: light and electron microscopy study.

The initial presentation of scleroderma (systemic sclerosis) with a manifestation involving only the breast has not been reported in the literature. Previous reports document scleroderma occurring after cosmetic mammaplasties. The presumed etiology is related to silicone, which has some adjuvant effect in development of the disease. This report documents a case of scleroderma presenting as a breast problem in a 28-year-old woman without prior exposure to silicone. We also describe the light and electron microscopy findings.