Comparison the Effects of Two Different Doses of Dexmedetomidine and Propofol on Intraoperative Sedation; Hemodynamic Changes and Postoperative Complications in Patients Undergoing Ovarian Puncture Surgery.

BACKGROUND

This study aimed to evaluate the effects of different doses of dexmedetomidine and propofol on sedation, hemodynamic changes, and postoperative complications in patients undergoing ovarian puncture surgery.

MATERIALS AND

METHODS

This randomized controlled trial was conducted on 96 women candidates for ovarian puncture surgery. In the first group (DEX-0.5), a bolus dose of dexmedetomidine 0.5 µg/kg was administered for the induction of anesthesia, followed by a maintenance dose of dexmedetomidine 0.5 µg/kg/min. In the second group (DEX-1), a bolus dose of dexmedetomidine 1 µg/kg was administered for induction, followed by a maintenance dose of dexmedetomidine 1 µg/kg/min. In the third group (control group), propofol 50 µg/kg/min was administered for induction of anesthesia.

RESULTS

SBP, DBP, and MAP were significantly lower in the control group compared to the other groups (P value < 0.05). The mean scores of patient and surgical satisfaction levels in the DEX-0.5 group were significantly higher than the control group (4.00 ± 1.02 and 4.41 ± 0.57, respectively) and in the DEX-1 group (6.00 ± 1.35 and 4.61 ± 0.56, respectively) compared to the control group (2.90 ± 2.10 and 3.10 ± 0.32, respectively) (P value < 0.05). Need for additional analgesics was significantly higher in the control group compared to the intervention groups (P value < 0.05).

CONCLUSION

It seems that the administration of dexmedetomidine 1 µg/kg, due to better pain relief, higher satisfaction, less need for additional analgesics, and minimal occurrence of complications, can be recommended as a safe and effective dose in ovarian puncture surgery.