Respirology (Carlton, Vic.) · 2025
Inspiratory Muscle Training on Exercise Capacity, Dyspnoea and Health Status in Pulmonary Hypertension: A Randomised Controlled Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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da Fontoura Fabrício Farias, Roncato Gabriela, Meyer Gisela Martina Bohns, da Luz Goulart Cássia, Spilimbergo Fernanda Brum, Cipriano Junior Gerson, Bernadeli Marilia Gabriela, Rigatto Katya, Berton Danilo Cortozi
Аннотация
BACKGROUND AND OBJECTIVE: To evaluate the effects of a high-intensity inspiratory muscle training on respiratory muscle strength, exercise capacity, dyspnoea, and health-related quality of life (HRQL) in patients with pulmonary hypertension (PH).
METHODS: Single-blinded, randomised controlled trial 35 women with clinically stable PH (subgroups 1 and 4), functional class II and III, were randomly assigned to a high-intensity inspiratory muscle training (IMT) or sham training. Daily 8-week IMT protocol with 50% (IMT-50%) of maximal inspiratory muscle pressure (PImax) or sham training with a fixed load of 3 cmH2O (IMT-S). Daily training time consisted of 2 cycles of 30 dynamic inspiratory efforts twice daily, 7 days/week, for 8 weeks using an inspiratory threshold-loading device.
RESULTS: There were significantly greater improvements in the intervention group (17 patients) compared to sham (14 patients) on PImax [Δpost-pre = 56.4 cmH2O (95% CI 63.5 to 49.3) versus IMT-S 25.2 cmH2O (95% CI 33.1 to 17.4), p < 0.001]. The intervention group improved their 6MWT [Δpost-pre, IMT 50% = 33.5 m (95% CI 15.9 to 51.2) vs. IMT-S -1.1 m (95% CI -26.7 to 24.4), p < 0.001]. Dyspnoea perception at the end of the 6-min walk test (6MWT) and mMRC significantly improved in the IMT-50% group: Dyspnoea [Δpost-pre = -1.1 (95% CI -1.5 to -0.7) vs. IMT-S -0.2 (95% CI -1.3 to 0.9), p < 0.001] and mMRC [Δpost-pre = -0.6 (95% CI -0.8 to 0.3) vs. IMT-S 0 (95% CI -0.2 to 0.2), p < 0.001].
CONCLUSIONS: A high-intensity protocol of IMT improves respiratory muscle strength, exercise capacity, and dyspnoea in symptomatic patients with PH.
TRIAL REGISTRATION: The trial was recorded on the Trials registry RBR-33gm3k (https://ensaiosclinicos.gov.br/rg/RBR-33gm3k).
METHODS: Single-blinded, randomised controlled trial 35 women with clinically stable PH (subgroups 1 and 4), functional class II and III, were randomly assigned to a high-intensity inspiratory muscle training (IMT) or sham training. Daily 8-week IMT protocol with 50% (IMT-50%) of maximal inspiratory muscle pressure (PImax) or sham training with a fixed load of 3 cmH2O (IMT-S). Daily training time consisted of 2 cycles of 30 dynamic inspiratory efforts twice daily, 7 days/week, for 8 weeks using an inspiratory threshold-loading device.
RESULTS: There were significantly greater improvements in the intervention group (17 patients) compared to sham (14 patients) on PImax [Δpost-pre = 56.4 cmH2O (95% CI 63.5 to 49.3) versus IMT-S 25.2 cmH2O (95% CI 33.1 to 17.4), p < 0.001]. The intervention group improved their 6MWT [Δpost-pre, IMT 50% = 33.5 m (95% CI 15.9 to 51.2) vs. IMT-S -1.1 m (95% CI -26.7 to 24.4), p < 0.001]. Dyspnoea perception at the end of the 6-min walk test (6MWT) and mMRC significantly improved in the IMT-50% group: Dyspnoea [Δpost-pre = -1.1 (95% CI -1.5 to -0.7) vs. IMT-S -0.2 (95% CI -1.3 to 0.9), p < 0.001] and mMRC [Δpost-pre = -0.6 (95% CI -0.8 to 0.3) vs. IMT-S 0 (95% CI -0.2 to 0.2), p < 0.001].
CONCLUSIONS: A high-intensity protocol of IMT improves respiratory muscle strength, exercise capacity, and dyspnoea in symptomatic patients with PH.
TRIAL REGISTRATION: The trial was recorded on the Trials registry RBR-33gm3k (https://ensaiosclinicos.gov.br/rg/RBR-33gm3k).