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British journal of obstetrics and gynaecology · 1999

In vivo assessment of failed trophoblastic invasion of the spiral arteries in pre-eclampsia.

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Matijevic R, Johnston T

Аннотация

OBJECTIVE: To assess the ability of colour/pulsed Doppler ultrasound to detect failed physiologic change of the spiral arteries in pregnancies complicated by pre-eclampsia.

DESIGN: Prospective matched-pairs case controlled study.

SETTING: Tertiary referral teaching hospital.

SAMPLE: Sixteen women with severe pre-eclampsia and 16 normotensive controls.

METHODS: Colour/pulsed Doppler assessment of blood flow in the uterine arteries and spiral arteries in central and peripheral parts of the placental bed.

MAIN OUTCOME MEASURES: Impedance to blood flow in the spiral arteries in pre-eclamptic group compared with normotensive controls.

RESULTS: In women with pre-eclampsia there is significantly higher impedance to blood flow in spiral arteries compared with normotensive women.

CONCLUSIONS: Ultrasound colour/pulsed Doppler based investigation of blood flow in the spiral arteries in ongoing pregnancy can detect failed physiological change of these vessels in pre-eclampsia. This is in concordance with histologic data.

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