Ultra-Efficient Solid-Phase Peptide Synthesis.

Microwave peptide synthesis offers significant advantages for peptide production in speed, efficiency, and overall purity. This chapter surveys key developments including the introduction of a wash-free methodology that has enabled 95% waste reduction in peptide synthesis at both research and production level solid-phase peptide synthesis (SPPS). Microwave SPPS is a widely used technique for R&D scale peptide synthesis with more recent expansion into larger scale current good manufacturing practice (cGMP).