Veterinary anaesthesia and analgesia · 2025
Comparing intramuscular ketamine with peri-incisional bupivacaine with or without ketamine in dogs undergoing hemilaminectomy.
Сравнительное исследованиеСтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Cambruzzi Martina, McFadzean William Jm, Covey-Crump Gwen, Deutsch Julia
Аннотация
OBJECTIVE: To investigate whether infiltrating bupivacaine with ketamine into the epaxial muscles improves quality and duration of analgesia perioperatively compared with bupivacaine alone or ketamine intramuscularly.
STUDY DESIGN: Prospective blinded randomized clinical study.
ANIMALS: A group of 66 dogs randomized into three groups (n = 22).
METHODS: Before surgery, bupivacaine 0.5% 2 mg kg-1 alone (group B) or combined with ketamine 2 mg kg-1 (group BK) was infiltrated peri-incisionally into the epaxial muscles. Group K received ketamine 2 mg kg-1 injected intramuscularly into a cervical muscle without infiltration. Meloxicam 0.2 mg kg-1 was given intravenously (IV) before moving to theatre. Cardiovascular variables: heart rate and systolic, mean and diastolic blood pressure were recorded. Intraoperative fentanyl 5 μg kg-1 IV was administered if these variables increased by 20% from baseline. Fentanyl continuous infusion (5 μg kg-1 hour-1) was started if more than three boluses were required. The Glasgow Composite Pain Scale-Short Form was used pre- and postoperatively for acute pain assessment at different time intervals; methadone 0.2 mg kg-1 IV was administered if scores were greater 5/20. Analgesia requirements, time to first administration, pain scores, total opioids interventions, need for sedation, first food intake and adverse effects were recorded. Continuous, normally distributed and non-normally distributed variables were analysed using ANOVA or Kruskal Wallis test, respectively.
RESULTS: No significant difference was found for cardiovascular variables between groups over time, intra- or postoperative analgesia requirements, time to administration, pain scores total opioids, time to first food intake, sedation and occurrence of adverse effects.
CONCLUSIONS AND CLINICAL RELEVANCE: No difference in perioperative rescue analgesia was found between groups.
STUDY DESIGN: Prospective blinded randomized clinical study.
ANIMALS: A group of 66 dogs randomized into three groups (n = 22).
METHODS: Before surgery, bupivacaine 0.5% 2 mg kg-1 alone (group B) or combined with ketamine 2 mg kg-1 (group BK) was infiltrated peri-incisionally into the epaxial muscles. Group K received ketamine 2 mg kg-1 injected intramuscularly into a cervical muscle without infiltration. Meloxicam 0.2 mg kg-1 was given intravenously (IV) before moving to theatre. Cardiovascular variables: heart rate and systolic, mean and diastolic blood pressure were recorded. Intraoperative fentanyl 5 μg kg-1 IV was administered if these variables increased by 20% from baseline. Fentanyl continuous infusion (5 μg kg-1 hour-1) was started if more than three boluses were required. The Glasgow Composite Pain Scale-Short Form was used pre- and postoperatively for acute pain assessment at different time intervals; methadone 0.2 mg kg-1 IV was administered if scores were greater 5/20. Analgesia requirements, time to first administration, pain scores, total opioids interventions, need for sedation, first food intake and adverse effects were recorded. Continuous, normally distributed and non-normally distributed variables were analysed using ANOVA or Kruskal Wallis test, respectively.
RESULTS: No significant difference was found for cardiovascular variables between groups over time, intra- or postoperative analgesia requirements, time to administration, pain scores total opioids, time to first food intake, sedation and occurrence of adverse effects.
CONCLUSIONS AND CLINICAL RELEVANCE: No difference in perioperative rescue analgesia was found between groups.