Enantio- and Regioselective Access to Chiral α-Amino Ketones via Nickel/Photoredox Catalysis.

A novel nickelaphotoredox platform enables highly enantio- and regioselective carboacylation of alkenes with alkyl boronate salts and acyl chlorides for the modular asymmetric synthesis of α-amino ketone derivatives. This redox-neutral protocol features a broad substrate scope and scalability and enables ready transformation into valuable chiral synthons and bioactive molecules. Mechanistic studies were undertaken to elucidate the reaction pathway of this alkene difunctionalization.