D-amphetamine-like stimulus properties are produced by morphine injections into the ventral tegmental area but not into the nucleus accumbens.

We investigated whether injections of morphine into the ventral tegmental area (VTA) or the nucleus accumbens (NAS) could produce amphetamine-like stimulus properties and locomotor stimulant effects. Rats were trained to discriminate 1.0 mg/kg D-amphetamine from saline using both VI-30 and FR-16 reinforcement schedules and they were then tested following bilateral injections of morphine sulfate (2.5, 5.0 and 10.0 micrograms/side) either into the VTA or the NAS. Intra-VTA injections of morphine produced significant increases in amphetamine-lever responding that were comparable to increases observed following intra-NAS D-amphetamine (2.5, 5.0 and 10.0 micrograms/side). Such increases were not observed, however, following intra-NAS injections of morphine. Tests for the effects of intracerebral morphine and D-amphetamine on locomotor activity produced a similar pattern of results. Locomotor activity was increased following intra-VTA morphine and intra-NAS D-amphetamine injections, but not after intra-NAS morphine injections. Together, these findings indicate that activation of opioid receptors within the VTA, but not the NAS, can produce a behavioral state which mimics to some degree the state produced by systemic and intra-NAS injections of D-amphetamine.