Diagnostic Accuracy of Shear-Wave Elastography for Breast Lesion Characterization in Women: A Systematic Review and Meta-Analysis.

PURPOSE: The aim of this study was to assess the diagnostic accuracy of 2-D shear-wave elastography (SWE) for differentiating benign and malignant breast lesions in women with abnormal findings on mammography.

METHODS

Included in this review are studies of diagnostic accuracy published before June 2021 using 2-D SWE to evaluate female breast lesions. Included studies were required to include at least 50 lesions, report quantitative shear-wave speed (SWS) thresholds, and include a reference standard of either biopsy or 2-year stability. Included studies used the mean, maximum, minimum, or SD of SWS for classification. A systematic search of PubMed, Scopus, Embase, Ovid-MEDLINE, the Cochrane Library, and Web of Science was performed. Bias and applicability of the studies were assessed using Quality Assessment of Diagnostic Accuracy Studies 2. A hierarchical summary receiver operating characteristic model was used to arrive at the summary statistics.

RESULTS

Eighty-seven prospective and retrospective studies were included, encompassing 17,810 women (mean age 42.3 ± 10.4 years) with 19,043 lesions (7,623 malignant). Summary sensitivities and specificities, respectively, were 0.86 (95% confidence interval [CI], 0.83-0.88) and 0.87 (95% CI, 0.84-0.88) for mean SWS, 0.83 (95% CI, 0.80-0.85) and 0.88 (95% CI, 0.86-0.90) for the maximum, 0.86 (95% CI, 0.74-0.93) and 0.81 (95% CI, 0.69-0.89) for the minimum, and 0.82 (95% CI, 0.77-0.86) and 0.88 (95% CI, 0.85-0.91) for the SD. Alternatively, the areas under the receiver operating characteristic curve were 0.93 (95% CI, 0.91-0.94), 0.92 (95% CI, 0.90-0.94), 0.90 (95% CI, 0.82-0.96), and 0.92 (95% CI, 0.88-0.94), respectively.

CONCLUSIONS

This review demonstrates the discriminative power of SWE in the diagnosis of breast cancer. Using the resulting likelihood ratios, SWE may prove beneficial in downgrading BI-RADS® 4a or upgrading BI-RADS 3 lesions. However, current society guidelines do not provide definitive recommendations regarding the use of SWE and its counterpart strain elastography (SE). Comparison with our results suggests that SE alone or a combination of SE and SWE may provide better diagnostic performance than SWE alone and serve as an adjunct to current diagnostic techniques.