Skin Regeneration in Diabetic Rats Using Gold Nanoparticles-Bioactive Glass Oil-in-Water Cream.

Diabetes is a chronic disease that severely impairs wound healing, slowing wound closure; thus, the risk of infection and increases the occurrence of other complications. The development of a suitable material that can accelerate the process of chronic wound regeneration, particularly in diabetic wounds, remains a significant challenge. In the present study, Sepigel 305® paraffin-based oil-in-water cream containing spherical gold nanoparticles-bioactive glass was used in rats with induced diabetes mellitus. After wound closure, the stage of regeneration was evaluated histopathologically. It was shown that the wounds treated with the experimental product were closed macroscopically after 14 days, but the histological images still indicated an inflammatory process, suggesting incomplete deep dermal healing. Macroscopic closure of wounds treated with the studied cream after 14 days, which is a normal time for skin healing, represents a successful outcome in diabetic patients because the risk of bacterial infection is reduced, and thus the chance of complete healing increases.