Science (New York, N.Y.) · 2001
A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Miller M A, Nguyen V Q, Lee M H, Kosinski M, Schedl T, Caprioli R M, Greenstein D
Аннотация
Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation. We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction. MSP also functions in sperm locomotion, playing a role analogous to actin. Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla.
Предметные рубрики MeSH
Amino Acid SequenceAnimalsCaenorhabditis elegansCarrier ProteinsCytoskeletonDisorders of Sex DevelopmentEnzyme ActivationEvolution, MolecularFemaleGonadsHelminth ProteinsMAP Kinase Signaling SystemMaleMeiosisMembrane ProteinsMicroinjectionsMitogen-Activated Protein KinasesMolecular Sequence DataOocytesOvulationPhylogenyProtein FoldingProtein Structure, TertiaryPseudopodiaRecombinant ProteinsSignal TransductionSperm MotilitySpermatozoa