Infectious agents and cancer · 2018
Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma.
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Crosslin David R, Robertson Peggy D, Carrell David S, Gordon Adam S, Hanna David S, Burt Amber, Fullerton Stephanie M, Scrol Aaron, Ralston James, Leppig Kathleen, Hartzler Andrea, Baldwin Eric, Andrade Mariza de, Kullo Iftikhar J, Tromp Gerard, Doheny Kimberly F, Ritchie Marylyn D, Crane Paul K, Nickerson Deborah A, Larson Eric B, Jarvik Gail P
Аннотация
PURPOSE: The Montreal Cognitive Assessment (MoCA) is a validated screening tool for cognitive impairment (CI) in surgical populations that assesses multiple cognitive domains. The primary objective of this report was to characterize preoperative domain-specific performance on the MoCA in older surgical patients. The secondary objectives were to explore preoperative characteristics and adverse outcomes associated with poorer domain-specific performance.
METHODS: This was a post hoc analysis of the Detection of Cognitive Impairment (Detect CI) study. The MoCA was administered preoperatively to assess seven cognitive domains: executive/visuospatial function, naming, attention, language, abstraction, delayed recall, and orientation. It was scored out of 30, with higher education-adjusted MoCA scores indicating better cognitive performance and scores ≤ 25 classifying probable CI. Adverse outcomes were collected in 382 participants at 30 days and 379 participants at 90 days postoperatively.
RESULTS: The 382 participants (median age, 73 years [IQR, 68, 77]; 58% female) had a mean MoCA score of 25.9 ± 2.8, with 35% screening positive for CI. Participants with probable CI performed significantly poorer across all seven cognitive domains (executive/visuospatial function, naming, attention, language, abstraction, delayed recall, and orientation) than those without CI. Having ≤ 12 years of education was associated with poorer executive/visuospatial function, naming, language, abstraction, and delayed recall. Of all cognitive domains, exploratory analyses showed that only orientation was associated with 30-day adverse outcomes after adjusting for age, sex, education level, and/or American Society of Anesthesiologists status and within-domain multiplicity. Each one-point decrease in orientation score was associated with a longer length of stay (β = 0.5, 95% confidence interval [95% CI] 0.2-0.8; P = 0.012) and higher adjusted odds of postoperative delirium (adjusted odds ratio [aOR] = 11.4, 95% CI 2.6-46.8; P = 0.004), complications (aOR = 3.1, 95% CI 1.3-8.9; P = 0.035), non-home discharge (aOR = 4.1, 95% CI 1.5-11.4; P = 0.014), and composite adverse outcomes (aOR = 5.6, 95% CI 1.9-23.9; P = 0.014). Orientation remained associated with postoperative delirium after adjusting for multiplicity both within and across MoCA domains (aOR = 11.4, 95% CI 2.6-46.8; P = 0.031).
CONCLUSIONS: This analysis characterized preoperative domain-specific performance on the MoCA in older adults, with participants screening positive for CI exhibiting poorer performance across all cognitive domains. Exploratory findings suggested that orientation difficulties may be associated with early adverse outcomes, with postoperative delirium showing the most robust association.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44254-026-00181-2.
METHODS: This was a post hoc analysis of the Detection of Cognitive Impairment (Detect CI) study. The MoCA was administered preoperatively to assess seven cognitive domains: executive/visuospatial function, naming, attention, language, abstraction, delayed recall, and orientation. It was scored out of 30, with higher education-adjusted MoCA scores indicating better cognitive performance and scores ≤ 25 classifying probable CI. Adverse outcomes were collected in 382 participants at 30 days and 379 participants at 90 days postoperatively.
RESULTS: The 382 participants (median age, 73 years [IQR, 68, 77]; 58% female) had a mean MoCA score of 25.9 ± 2.8, with 35% screening positive for CI. Participants with probable CI performed significantly poorer across all seven cognitive domains (executive/visuospatial function, naming, attention, language, abstraction, delayed recall, and orientation) than those without CI. Having ≤ 12 years of education was associated with poorer executive/visuospatial function, naming, language, abstraction, and delayed recall. Of all cognitive domains, exploratory analyses showed that only orientation was associated with 30-day adverse outcomes after adjusting for age, sex, education level, and/or American Society of Anesthesiologists status and within-domain multiplicity. Each one-point decrease in orientation score was associated with a longer length of stay (β = 0.5, 95% confidence interval [95% CI] 0.2-0.8; P = 0.012) and higher adjusted odds of postoperative delirium (adjusted odds ratio [aOR] = 11.4, 95% CI 2.6-46.8; P = 0.004), complications (aOR = 3.1, 95% CI 1.3-8.9; P = 0.035), non-home discharge (aOR = 4.1, 95% CI 1.5-11.4; P = 0.014), and composite adverse outcomes (aOR = 5.6, 95% CI 1.9-23.9; P = 0.014). Orientation remained associated with postoperative delirium after adjusting for multiplicity both within and across MoCA domains (aOR = 11.4, 95% CI 2.6-46.8; P = 0.031).
CONCLUSIONS: This analysis characterized preoperative domain-specific performance on the MoCA in older adults, with participants screening positive for CI exhibiting poorer performance across all cognitive domains. Exploratory findings suggested that orientation difficulties may be associated with early adverse outcomes, with postoperative delirium showing the most robust association.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44254-026-00181-2.