IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis.

BACKGROUND

IgG4-related systemic disease (IgG4-RSD) is a recently recognised fibroinflammatory condition, characterized by a tissue infiltration and/or enlargement and typical histopathological findings.

METHODS AND

RESULTS

We report on a 73-year-old male with bilateral preauricular swelling and a remote history of unexplained systemic disease. Magnetic resonance imaging showed enlargement of all major salivary glands and cervical lymph node due to a tissue infiltration with marked enhancement and restricted diffusion. Elevated serum IgG4 levels and histopathological findings on an excisional lymph node biopsy were consistent with IgG4-RSD.

CONCLUSION

Magnetic resonance imaging seems to be a useful tool to support the diagnosis of IgG4-related systemic disease of salivary glands.