JACC. Case reports · 2026
Over-the-Counter Loperamide Overdose Resulting in Cardiac Arrest.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Everingham Margaux, Bolte Ashley C, Goldberg Elliott, Michienzi Avery, Bazydlo Lindsay A L, Stafford Patrick L
Аннотация
BACKGROUND: Over-the-counter loperamide at high doses can lead to QT prolongation and cardiac arrest.
CASE SUMMARY: We present a case of a woman with cardiac arrest due to ventricular tachycardia storm. Overdrive pacing, antiarrhythmic medications, and deep sedation were used to manage the recurrent ventricular tachycardia. Untargeted urine testing helped determine the etiology of the arrest may be loperamide overdose, and this was later confirmed on patient interview and targeted testing. The patient was discharged without the need for an implanted defibrillator.
DISCUSSION: Multiple over-the-counter medications, such as loperamide and diphenhydramine, can result in QT prolongation at high doses and therefore can be a cause of arrhythmia and cardiac arrest.
TAKE-HOME MESSAGES: In cases of cardiac arrest in patients where overdose is suspected, untargeted urine testing through mass spectrometry may be helpful in determining the etiology to guide therapies and prevent unnecessary medical interventions.
CASE SUMMARY: We present a case of a woman with cardiac arrest due to ventricular tachycardia storm. Overdrive pacing, antiarrhythmic medications, and deep sedation were used to manage the recurrent ventricular tachycardia. Untargeted urine testing helped determine the etiology of the arrest may be loperamide overdose, and this was later confirmed on patient interview and targeted testing. The patient was discharged without the need for an implanted defibrillator.
DISCUSSION: Multiple over-the-counter medications, such as loperamide and diphenhydramine, can result in QT prolongation at high doses and therefore can be a cause of arrhythmia and cardiac arrest.
TAKE-HOME MESSAGES: In cases of cardiac arrest in patients where overdose is suspected, untargeted urine testing through mass spectrometry may be helpful in determining the etiology to guide therapies and prevent unnecessary medical interventions.