The Journal of pediatrics · 2011
Neurodevelopmental outcomes in infants requiring resuscitation in developing countries.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Carlo Waldemar A, Goudar Shivaprasad S, Pasha Omrana, Chomba Elwyn, McClure Elizabeth M, Biasini Fred J, Wallander Jan L, Thorsten Vanessa, Chakraborty Hrishikesh, Wright Linda L, Brain Research to Ameliorate Impaired Neurodevelopment-Home-based Intervention Trial Committee, National Institute of Child Health and Human Development Global Network for Women’s and Children’s Health Research
Аннотация
OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment.
STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported.
RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index <85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P = .22) and in other neurodevelopmental outcomes.
CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments.
STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported.
RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index <85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P = .22) and in other neurodevelopmental outcomes.
CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments.
Предметные рубрики MeSH
Child DevelopmentDeveloping CountriesDevelopmental DisabilitiesFemaleHumansIncidenceIndiaInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightLearning DisabilitiesMaleMental DisordersNeuropsychological TestsPakistanReference ValuesRespiratory Distress Syndrome, NewbornResuscitationRisk AssessmentRural PopulationSeverity of Illness IndexSurvival AnalysisZambia