Masui. The Japanese journal of anesthesiology · 2002
[The effects of intrathecally administered neostigmine on somato-sympathetic reflex potentials].
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Saeki Shigeru, Kakishita Michiko, Nakamura Takashi, Kobayashi Terukazu, Ogawa Setsuro
Аннотация
BACKGROUND: Antinociceptive effect of intrathecal neostigmine has been investigated using withdrawal responses in laboratory experiments. However, neostigmine administered in this route can induce muscle weakness or sedation. As a result, these effect can modify withdrawal responses. In this study we investigated the antinociceptive effect of intrathecally administered neostigmine bromide (NB) in cats objectively and quantitatively using somato-sympathetic reflex potentials.
METHODS: Anesthetized cats were inserted with a spinal catheter via atlanto-occipital membrane and 10 micrograms (n = 5), 50 micrograms (n = 5), 250 micrograms (n = 8) or 2 mg (n = 5) of NB was administered through this route. Somato-sympathetic reflex potentials (A and C reflex) derived from lumbar sympathetic ganglion by stimulation of the femoral nerve and mean arterial blood pressure (MAP) and heart rate (HR) in each dose were monitored and recorded.
RESULTS: Reflex potential was reduced in a dose dependent fashion by NB but these changes were not significant. On the other hand, 250 micrograms and 2 mg of NB maximally reduced C reflex potential to 55.2% and 24.0% of control values respectively 20 minutes after the administration (P < 0.01), and this reduction was reversed by 250 to 2 mg of intrathecal administration of atropine sulfate to 89.4%, 68.6% of control values respectively. MAP and HR decreased in dose dependent fashion by NB to 57.6%, 65.2% of control values after the administration of 2 mg of NB and these cardiovascular changes recovered by intrathecally administered atropine sulfate.
CONCLUSION: These results objectively indicate that intrathecally administered neostigmine bromide shows antinociceptive effect and this inhibition is partially mediated by cholinergic mechanism.
METHODS: Anesthetized cats were inserted with a spinal catheter via atlanto-occipital membrane and 10 micrograms (n = 5), 50 micrograms (n = 5), 250 micrograms (n = 8) or 2 mg (n = 5) of NB was administered through this route. Somato-sympathetic reflex potentials (A and C reflex) derived from lumbar sympathetic ganglion by stimulation of the femoral nerve and mean arterial blood pressure (MAP) and heart rate (HR) in each dose were monitored and recorded.
RESULTS: Reflex potential was reduced in a dose dependent fashion by NB but these changes were not significant. On the other hand, 250 micrograms and 2 mg of NB maximally reduced C reflex potential to 55.2% and 24.0% of control values respectively 20 minutes after the administration (P < 0.01), and this reduction was reversed by 250 to 2 mg of intrathecal administration of atropine sulfate to 89.4%, 68.6% of control values respectively. MAP and HR decreased in dose dependent fashion by NB to 57.6%, 65.2% of control values after the administration of 2 mg of NB and these cardiovascular changes recovered by intrathecally administered atropine sulfate.
CONCLUSION: These results objectively indicate that intrathecally administered neostigmine bromide shows antinociceptive effect and this inhibition is partially mediated by cholinergic mechanism.