Photocatalytic 1,2,3-Trifunctionalization of β,γ-Unsaturated Ketones via 1,2-Carbonyl Migration to Access Functionalized Indanones.

Rearrangement reactions are powerful tools in organic synthesis for the construction of new organic molecular scaffolds. Herein we report a photocatalytic radical-mediated 1,2-carbonyl migration of β,γ-unsaturated ketones with α-carbonyl alkyl bromides, producing a wide range of valuable functionalized indanones. This transformation involves a sequential process of alkyl radical generation, radical addition, 1,2-carbonyl rearrangement, annulation, and deprotonation in a single step.