Concurrent multiple odontogenic keratocysts and odontogenic myxoma in a patient with nevoid basal cell carcinoma: a case report and literature review.

Odontogenic myxoma and odontogenic keratocyst (OKC) rarely coexist, especially in association with Nevoid Basal Cell Carcinoma Syndrome (NBCCS). This report presents an unusual case of an NBCCS patient with simultaneous myxoma and OKC in the mandible. We introduce an innovative management strategy incorporating 5-fluorouracil (5-FU) as an adjunct treatment for OKC, paired with immediate mandibular reconstruction using a fibula-free flap, following the Jaw-In-A-Day (JIAD) protocol. The report details the clinical presentation, surgical approach, and follow-up, highlighting the potential benefits of this treatment combination for managing concurrent odontogenic lesions. Additionally, a comprehensive review of existing literature is provided.