Anaphylactic and anaphylactoid causes of angioedema.

Anaphylactic and anaphylactoid (pseudoallergic) reactions can be expected to occur with greater frequency as the number of immunomodulators are employed. The immune system will become sensitized to these new therapeutic agents or there may be first-dose reactions depending on the pathogenetic mechanism involved. Physicians should review their office or procedure room emergency preparedness protocols and medications. The lack of penicillin major and minor determinants for penicillin testing has made management of penicillin and cephalosporin allergic patients more complicated. In the absence of skin-testing materials, test-challenges will be necessary and performed with less comfort because of not knowing the current level of immunologic sensitization to penicillin. The indication for readministration of any incriminated medication/therapeutic agent should be reviewed. Often, there are not suitable alternatives. Various approaches have been presented to permit safer readministration of essential medications or diagnostic agents to prevent episodes of anaphylaxis or upper airway angioedema.