Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population.

Postoperative nausea and vomiting (PONV) is one of the adverse effects that can occur repeatedly during the initial twenty-four hours following surgery. The objective of this study was to investigate parameters that may predict PONV in patients undergoing rhinoplasty surgery. The demographic data of the patients, including preoperative neutrophil, lymphocyte, and platelet counts, were obtained from patient records. Inclusion criteria comprised patients aged 18-35 years in ASA I category, those without systemic disease or with controlled systemic disease, and patients without a history of blood transfusion or use of antiemetic medications. Patients with a history of blood transfusion or antiemetic drug use were excluded from the study. Patients were categorized into PONV (group 1) and control (group 2) groups. The incidence of PONV, metoclopramide dosage, severity of nausea, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were evaluated preoperatively. The groups exhibited similar demographic characteristics, and all confounding factors (age, duration of anesthesia, blood type) were equalized (P < 0.05). In the PONV group, the number of female patients exceeded that of male patients (approximately twofold). However, this difference was not statistically significant (P > 0.05). The preoperative NLR and PLR in the PONV group were significantly higher than in the control group (P < 0.05). No significant correlation was observed between preoperative platelet count and the occurrence of postoperative nausea (P > 0.05). Preoperative NLR and PLR parameters may be effective in predicting PONV. A treatment strategy based on these parameters could potentially play a crucial role in preventing PONV.