Auto-antibodies of the IgD class.

Utilizing immunofluorescent techniques, antinuclear and antithyroid antibodies were demonstrated within the IgD class of immunoglobulins. Glomerular deposits of IgD were detected in three kidneys with glomerulonephritis and one renal allograft. Similar deposits were not present in four kidneys with respective diagnosis of interstitial nephritis, lupus nephritis, chronic glomerulonephritis, and focal glomerulonephritis. IgD antibodies may be formed in response to a variety of antigenic stimuli and are present in some autoimmune disorders. The detection of glomerular deposits of IgD suggests that immunoglobulins of this class may be present in association with some immunologically induced lesions.