Inflammatory intestinal diseases · 2026
Impact of Bowel Rest on Hospitalized Patients with Ulcerative Colitis.
СтатьяНазвание и аннотация: Перевод в очереди
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Shu Nobuaki, Ohta Yuki, Kato Jun, Shimizu Kento, Arakawa Hiromi, Matsubara Yoshiki, Ohashi Takuya, Ozaki Tomomi, Ito Toshiyuki, Saito Ryo, Ozeki Yusuke, Iwasaki Miyuki, Furuya Makoto, Goto Chihiro, Horio Ryosuke, Kurosugi Akane, Sonoda Michiko, Ishikawa Tsubasa, Oura Hirotaka, Kaneko Tatsuya, Taida Takashi, Okimoto Kenichiro, Saito Keiko, Matsumura Tomoaki
Аннотация
INTRODUCTION: Bowel rest has traditionally been practiced for hospitalized patients with severe ulcerative colitis (UC). Most available evidence for bowel rest in UC originates from the prebiologic era. Therefore, this study evaluated the clinical impact of bowel rest in hospitalized patients with UC under modern therapy.
METHODS: A retrospective study was performed at a single tertiary hospital, where a change in institutional policy for hospitalized UC patients replaced essential bowel rest with early oral feeding in October 2019. Hospitalized UC patients were classified according to the timing of admission into a bowel rest group (group BR; February 2017-September 2019) and a non-bowel rest group (group non-BR; October 2019-October 2023). The primary outcome was colectomy avoidance. Secondary outcomes included hospital length of stay (LOS), central venous catheter (CVC) use, and related complications such as venous thromboembolism (VTE) and catheter-related bloodstream infection (CRBSI).
RESULTS: A total of 76 patients were analyzed (38 per group). Colectomy avoidance rate was similar in both groups (84.2% each, p = 0.98, log-rank test). Median LOS was shorter in group non-BR (22 vs. 31 days; p = 0.002). CVC use was more frequent (84.2% vs. 31.6%; p < 0.001) and longer (26 vs. 15 days; p = 0.001) in group BR. VTE and CRBSI rates did not differ between the two groups.
CONCLUSIONS: Among UC patients able to tolerate oral intake, oral intake was associated with shorter hospitalization and reduced CVC use, suggesting that routine bowel rest may not provide additional benefit.
METHODS: A retrospective study was performed at a single tertiary hospital, where a change in institutional policy for hospitalized UC patients replaced essential bowel rest with early oral feeding in October 2019. Hospitalized UC patients were classified according to the timing of admission into a bowel rest group (group BR; February 2017-September 2019) and a non-bowel rest group (group non-BR; October 2019-October 2023). The primary outcome was colectomy avoidance. Secondary outcomes included hospital length of stay (LOS), central venous catheter (CVC) use, and related complications such as venous thromboembolism (VTE) and catheter-related bloodstream infection (CRBSI).
RESULTS: A total of 76 patients were analyzed (38 per group). Colectomy avoidance rate was similar in both groups (84.2% each, p = 0.98, log-rank test). Median LOS was shorter in group non-BR (22 vs. 31 days; p = 0.002). CVC use was more frequent (84.2% vs. 31.6%; p < 0.001) and longer (26 vs. 15 days; p = 0.001) in group BR. VTE and CRBSI rates did not differ between the two groups.
CONCLUSIONS: Among UC patients able to tolerate oral intake, oral intake was associated with shorter hospitalization and reduced CVC use, suggesting that routine bowel rest may not provide additional benefit.