Urogynecology (Philadelphia, Pa.) · 2026
Postoperative Body Weight Changes and Effect on Midurethral Sling Failure.
Equivalence TrialСтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Glass Clark Stephanie M, Janmey Isabel, Bradley Megan S, Wang Li, Ackenbom Mary F
Аннотация
IMPORTANCE: Little is known about the effect of weight change following surgery on midurethral sling outcomes.
OBJECTIVE: The objective of this study was to determine the effect of body weight change after midurethral sling on the 24-month subjective outcome. We hypothesized that body weight gain would increase the chance of subjective failure.
STUDY DESIGN: This was a secondary analysis of the Trial of Mid-Urethral Slings. The primary outcome was subjective failure at 24 months postoperatively. Secondary outcomes include objective failure and combined (objective/subjective) failure at 24 months. Weight change was categorized as no change (if ±5 lb of baseline), gain (>5 lb above), and loss (>5 lb below) at baseline. In addition, we categorized for percentage weight change of baseline body weight (±5%, 5-10%, and >10%). The association between weight change and outcomes was evaluated using logistic regression.
RESULTS: Four hundred thirty-two participants were included. Weight loss or gain of >5 lb was not significantly associated with 24-month subjective failure (weight loss odds ratio [OR]: 1.54, 95% CI: 0.96-2.49; weight gain OR: 1.51, 95% CI: 0.96-2.36). In addition, no significant association was observed with 24-month objective or combined failure (Objective: weight loss OR: 1.23, 95% CI: 0.73-2.08; weight gain OR: 1.11, 95% CI: 0.67-1.82; Combined failure: weight loss OR: 1.32, 95% CI: 0.82-2.13, weight gain OR: 1.47, 95% CI: 0.94-2.31). Participants with weight gain >10% baseline body weight had significantly increased odds of combined failure at 24 months (OR: 2.75, 95% CI: 1.13-6.69).
CONCLUSIONS: Significant body weight gain (>10%) following midurethral sling placement is associated with increased odds of combined failure of the surgery at 24 months.
OBJECTIVE: The objective of this study was to determine the effect of body weight change after midurethral sling on the 24-month subjective outcome. We hypothesized that body weight gain would increase the chance of subjective failure.
STUDY DESIGN: This was a secondary analysis of the Trial of Mid-Urethral Slings. The primary outcome was subjective failure at 24 months postoperatively. Secondary outcomes include objective failure and combined (objective/subjective) failure at 24 months. Weight change was categorized as no change (if ±5 lb of baseline), gain (>5 lb above), and loss (>5 lb below) at baseline. In addition, we categorized for percentage weight change of baseline body weight (±5%, 5-10%, and >10%). The association between weight change and outcomes was evaluated using logistic regression.
RESULTS: Four hundred thirty-two participants were included. Weight loss or gain of >5 lb was not significantly associated with 24-month subjective failure (weight loss odds ratio [OR]: 1.54, 95% CI: 0.96-2.49; weight gain OR: 1.51, 95% CI: 0.96-2.36). In addition, no significant association was observed with 24-month objective or combined failure (Objective: weight loss OR: 1.23, 95% CI: 0.73-2.08; weight gain OR: 1.11, 95% CI: 0.67-1.82; Combined failure: weight loss OR: 1.32, 95% CI: 0.82-2.13, weight gain OR: 1.47, 95% CI: 0.94-2.31). Participants with weight gain >10% baseline body weight had significantly increased odds of combined failure at 24 months (OR: 2.75, 95% CI: 1.13-6.69).
CONCLUSIONS: Significant body weight gain (>10%) following midurethral sling placement is associated with increased odds of combined failure of the surgery at 24 months.