Tumori · 2016
Three patients with multiple myeloma developing secondary lymphoblastic leukemia: case reports and review of the literature.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Junxun Li, Junru Liu, Meilan Chen, Chujia Liang, Shaoqian Chen, Jieyu Zhan, Zhuangjian Ye, Fan Zhang, Juan Ouyang, Jing Cheng, Juan Li
Аннотация
INTRODUCTION: Secondary lymphoblastic leukemia has been rarely reported in patients with multiple myeloma.
CASE REPORTS: We report 3 cases of secondary lymphoblastic leukemia in multiple myeloma patients. They shared a similar phenotype of myeloma cells and secondary lymphoblasts. The chemotherapy treatments in the 3 patients were complex due to various factors.
CONCLUSIONS: Multiple immune defects caused by exposure to a variety of agents can play an important role in the development of secondary lymphoblastic leukemia. Microscopic morphology and flow cytometry are important means to detect secondary malignancies in multiple myeloma. Further clinical, experimental and genetic studies of secondary malignancies in multiple myeloma will be necessary in the future.
CASE REPORTS: We report 3 cases of secondary lymphoblastic leukemia in multiple myeloma patients. They shared a similar phenotype of myeloma cells and secondary lymphoblasts. The chemotherapy treatments in the 3 patients were complex due to various factors.
CONCLUSIONS: Multiple immune defects caused by exposure to a variety of agents can play an important role in the development of secondary lymphoblastic leukemia. Microscopic morphology and flow cytometry are important means to detect secondary malignancies in multiple myeloma. Further clinical, experimental and genetic studies of secondary malignancies in multiple myeloma will be necessary in the future.
Предметные рубрики MeSH
AchondroplasiaAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBone MarrowCombined Modality TherapyFemaleGene Rearrangement, B-LymphocyteHumansImmunophenotypingIn Situ Hybridization, FluorescenceMiddle AgedMultiple MyelomaNeoplasms, Second PrimaryPositron Emission Tomography Computed TomographyPrecursor Cell Lymphoblastic Leukemia-LymphomaTreatment Outcome